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AdreC57BL/6By
QTL Variant Detail
Summary
QTL variant: AdreC57BL/6By
Name: age at disappearance of rooting response; C57BL/6By
MGI ID: MGI:3612070
QTL: Adre  Location: unknown  Genetic Position: Chr4, Syntenic
Variant
origin
Strain of Specimen:  C57BL/6By
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers earlier disappearance of the rooting response in pups compared to BALB/cBy. (J:9001)
Inheritance:    Codominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes
The rooting response starts to disappear at 5 days after birth and is absent by the 10th day.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:9001

The rooting reponse refers to a behavior apparent at birth where the pup buries its snout underneath the mother's abdomen. This behavior disappears between 6 to 12 days after birth. In the inbred strain C57BL/6, rooting response begins to disappear at the fifth day after birth and is absent by the tenth day. In the inbred strain BALB/c, the rooting response begins to disappear at the seventh or eighth day after birth, but persists even after the twelveth day.

Genetic mapping of the rooting response trait was performed using 7 CXB (C=BALB/c; B=C57BL/6) recombinant inbred (RI) strains. A single locus named Adre (age at disappearance of rooting response) mapped to mouse Chromosome 4 near H21 (38 cM) and Tyrp1 (38 cM).

The existence of Adre on mouse Chromosome 4 was confirmed in the congenic strain B6.C-H21c/ByJ. This congenic carries BALB/c-derived DNA at the H21 locus on a C57BL/6 genetic background and exhibits later disappearance of the rooting response similar to the BALB/c donor strain.

J:105481

Genetic mapping of sensory development traits was performed using 7 recombinant inbred (RI) strains derived from C57BL/6By and BALB/cBy. The parental strain C57BL/6By is considered a fast developer compared to parental strain BALB/cBy.

The rooting reponse refers to a behavior apparent at birth where the pup buries its snout underneath the mother's abdomen. This behavior disappears between 6 to 12 days after birth. In the inbred strain C57BL/6By, rooting response begins to disappear at the fifth day afterbirth and is absent by the tenth day. In the inbred strain BALB/cBy, the rooting response begins to disappear at the seventh or eighth day after birth, but persists even after the twelfth day.

The disappearance of rooting response showed significant strain-dependent differences (p<0.001). The strain distribution pattern mapped a single locus named Adre (age at disappearance of rooting response) to mouse Chromosome 4 near H21 (38 cM) and Tyrp1 (38 cM). C57BL/6By-derived alleles at Adre confer faster disappearance of the rooting response with a codominant mode of inheritance.

Several other traits also exhibit significant strain-dependent effects but genetic loci have not yet been mapped. These traits include locomotion, righting response, hind limb placing, crossed extensor response, vibrissa placing, and bar holding.

References
Original:  J:105481 Roubertoux P, et al., Early development in mice: II; Sensory motor behavior and genetic analysis. Physiol Behav. 1985 Nov;35(5):659-66
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory