Adre^BALB/cBy
QTL Variant Detail

Summary

• QTL variant: Adre^BALB/cBy
• Name: age at disappearance of rooting response; BALB/cBy
• MGI ID: MGI:3612071
• QTL: Adre Location: unknown Genetic Position: Chr4, Syntenic

Variant origin

• Strain of Specimen: BALB/cBy

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers later disappearance of the rooting response in pups compared to C57BL/6By. (J:9001)
• Inheritance: Codominant

Notes

The rooting response starts to disappear at 7 or 8 days after birth, but may persist past the 12th day.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:9001

The rooting reponse refers to a behavior apparent at birth where the pup buries its snout underneath the mother's abdomen. This behavior disappears between 6 to 12 days after birth. In the inbred strain C57BL/6, rooting response begins to disappear at the fifth day after birth and is absent by the tenth day. In the inbred strain BALB/c, the rooting response begins to disappear at the seventh or eighth day after birth, but persists even after the twelveth day.

Genetic mapping of the rooting response trait was performed using 7 CXB (C=BALB/c; B=C57BL/6) recombinant inbred (RI) strains. A single locus named Adre (age at disappearance of rooting response) mapped to mouse Chromosome 4 near H21 (38 cM) and Tyrp1 (38 cM).

The existence of Adre on mouse Chromosome 4 was confirmed in the congenic strain B6.C-H21^c/ByJ. This congenic carries BALB/c-derived DNA at the H21 locus on a C57BL/6 genetic background and exhibits later disappearance of the rooting response similar to the BALB/c donor strain.

J:105481

Genetic mapping of sensory development traits was performed using 7 recombinant inbred (RI) strains derived from C57BL/6By and BALB/cBy. The parental strain C57BL/6By is considered a fast developer compared to parental strain BALB/cBy.

The rooting reponse refers to a behavior apparent at birth where the pup buries its snout underneath the mother's abdomen. This behavior disappears between 6 to 12 days after birth. In the inbred strain C57BL/6By, rooting response begins to disappear at the fifth day afterbirth and is absent by the tenth day. In the inbred strain BALB/cBy, the rooting response begins to disappear at the seventh or eighth day after birth, but persists even after the twelfth day.

The disappearance of rooting response showed significant strain-dependent differences (p<0.001). The strain distribution pattern mapped a single locus named Adre (age at disappearance of rooting response) to mouse Chromosome 4 near H21 (38 cM) and Tyrp1 (38 cM). C57BL/6By-derived alleles at Adre confer faster disappearance of the rooting response with a codominant mode of inheritance.

Several other traits also exhibit significant strain-dependent effects but genetic loci have not yet been mapped. These traits include locomotion, righting response, hind limb placing, crossed extensor response, vibrissa placing, and bar holding.

References

• Original: J:105481 Roubertoux P, et al., Early development in mice: II; Sensory motor behavior and genetic analysis. Physiol Behav. 1985 Nov;35(5):659-66
• All: 2 reference(s)