Ctl1^NZB/BlN
QTL Variant Detail

Summary

• QTL variant: Ctl1^NZB/BlN
• Name: cytotoxic T lymphocyte response 1; NZB/BlN
• MGI ID: MGI:3612085
• QTL: Ctl1 Location: unknown Genetic Position: Chr1, Syntenic

Variant origin

• Strain of Specimen: NZB/BlN

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers increased cytotoxic T lymphocyte response to H2-compatible cells compared to C57BL/10. (J:6736)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:6736

Linkage analysis was performed on a population of (NZB/BlN x B10.D2/oSnJ)F1 x B10.D2/oSnJ backcross animals to map loci affecting cytotoxic T lymphocyte (CTL) response to H2-compatible cells. Parental strain NZB/BlN exhibits increased in vitro CTL response to H2-compatible cells. Ctl1 (cytotoxic T lymphocyte response 1) showed linkage to mouse Chromosome 1 near Ly9 (93.9 cM). Animals heterozygous for NZB/BlN-derived alleles at Ctl1 exhibit stronger CTL response compared to animals homozygous for B10.D2/oSnJ-derived alleles.

References

• Original: J:6736 Davidson WF, et al., Chromosome 1 locus required for induction of CTL to H-2-compatible cells in NZB mice. Immunogenetics. 1982 Mar;15(3):321-5
• All: 1 reference(s)