Cxv1^F/St
QTL Variant Detail

Summary

• QTL variant: Cxv1^F/St
• Name: control of xenotropic virus 1; F/St
• MGI ID: MGI:3612091
• QTL: Cxv1 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: F/St

Variant description

• Allele Type: QTL
• Mutation: Undefined
• Mutation details: This allele confers high expression of the xenotropic murine leukemia virus (X-MuLV) in thymocytes compared to AKR/J. (J:7030)
• Inheritance: Recessive

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7030

Cxv1, a locus associated with high thymocyte expression of xenotropic murine leukemia virus (X-MuLV) and X-MuLV associated cell surface antigen (XenCSA), mapped near H2-K1 on mouse Chromosome 17 in a population of (AKR/J x F/St)F1 x F/St backcross animals. Parental strain F/St exhibits high X-MuLV and XenCSA expression in thymocytes. Cxv1 is recessively inherited with F/St-derived alleles conferring high X-MuLV and XenCSA thymocyte expression. Cxv1 is located approximately 1.9 cM from H2-K1.

Moreover, B10.F congenic animals carrying F/St-derived DNA at H2-K1 on a C57BL/10 genetic background exhibit high X-MuLV expression similar to the levels seen in donor strain F/St. This observation supports the existence of Cxv1 on mouse Chromosome 17 near H2-K1.

References

• Original: J:7030 Yetter RA, et al., H-2-linked regulation of xenotropic murine leukemia virus expression. Proc Natl Acad Sci U S A. 1983 Jan;80(2):505-9
• All: 1 reference(s)