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Cxv1AKR/J
QTL Variant Detail
Summary
QTL variant: Cxv1AKR/J
Name: control of xenotropic virus 1; AKR/J
MGI ID: MGI:3612092
QTL: Cxv1  Location: unknown  Genetic Position: Chr17, Syntenic
Variant
origin
Strain of Specimen:  AKR/J
Variant
description
Allele Type:    QTL
Inheritance:    Dominant
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:7030

Cxv1, a locus associated with high thymocyte expression of xenotropic murine leukemia virus (X-MuLV) and X-MuLV associated cell surface antigen (XenCSA), mapped near H2-K1 on mouse Chromosome 17 in a population of (AKR/J x F/St)F1 x F/St backcross animals. Parental strain F/St exhibits high X-MuLV and XenCSA expression in thymocytes. Cxv1 is recessively inherited with F/St-derived alleles conferring high X-MuLV and XenCSA thymocyte expression. Cxv1 is located approximately 1.9 cM from H2-K1.

Moreover, B10.F congenic animals carrying F/St-derived DNA at H2-K1 on a C57BL/10 genetic background exhibit high X-MuLV expression similar to the levels seen in donor strain F/St. This observation supports the existence of Cxv1 on mouse Chromosome 17 near H2-K1.

References
Original:  J:7030 Yetter RA, et al., H-2-linked regulation of xenotropic murine leukemia virus expression. Proc Natl Acad Sci U S A. 1983 Jan;80(2):505-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory