Summary |
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Variant origin |
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Variant description |
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:7030Cxv1, a locus associated with high thymocyte expression of xenotropic murine leukemia virus (X-MuLV) and X-MuLV associated cell surface antigen (XenCSA), mapped near H2-K1 on mouse Chromosome 17 in a population of (AKR/J x F/St)F1 x F/St backcross animals. Parental strain F/St exhibits high X-MuLV and XenCSA expression in thymocytes. Cxv1 is recessively inherited with F/St-derived alleles conferring high X-MuLV and XenCSA thymocyte expression. Cxv1 is located approximately 1.9 cM from H2-K1. Moreover, B10.F congenic animals carrying F/St-derived DNA at H2-K1 on a C57BL/10 genetic background exhibit high X-MuLV expression similar to the levels seen in donor strain F/St. This observation supports the existence of Cxv1 on mouse Chromosome 17 near H2-K1. |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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