Cartpt^tm1Amgn
Targeted Allele Detail

Summary

• Symbol: Cartpt^tm1Amgn
• Name: CART prepropeptide; targeted mutation 1, Amgen
• MGI ID: MGI:3612125
• Gene: Cartpt Location: Chr13:100034991-100037191 bp, - strand Genetic Position: Chr13, 52.9 cM, cytoband D1
• Alliance: Cartpt^tm1Amgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103911
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a HIS/neo cassette fusion ene replaced the entire coding sequence. Expression of mRNA was not detected in mutant hypothalamus. (J:103911)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cartpt Mutation: 15 strains or lines available

References

• Original: J:103911 Wierup N, et al., CART knock out mice have impaired insulin secretion and glucose intolerance, altered beta cell morphology and increased body weight. Regul Pept. 2005 Jul 15;129(1-3):203-11
• All: 3 reference(s)