P2ry4^tm1Brob
Targeted Allele Detail

Summary

• Symbol: P2ry4^tm1Brob
• Name: pyrimidinergic receptor P2Y, G-protein coupled, 4; targeted mutation 1, Bernard Robaye
• MGI ID: MGI:3612162
• Synonyms: P2Y4^-
• Gene: P2ry4 Location: ChrX:99633760-99638475 bp, - strand Genetic Position: ChrX, 43.72 cM, cytoband C2
• Alliance: P2ry4^tm1Brob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103975
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace 700 bp of the promoter region and 399 bp of the coding sequence with a neomycin resistance gene. Transcript was not detected in liver by RT-PCR analysis. (J:103975)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2ry4 Mutation: 5 strains or lines available

References

• Original: J:103975 Robaye B, et al., Loss of nucleotide regulation of epithelial chloride transport in the jejunum of P2Y4-null mice. Mol Pharmacol. 2003 Apr;63(4):777-83
• All: 7 reference(s)