mct1^BALB/cByJ
QTL Variant Detail

Summary

• QTL variant: mct1^BALB/cByJ
• Name: modifier of curly tail 1; BALB/cByJ
• MGI ID: MGI:3612266
• QTL: mct1 Location: unknown Genetic Position: Chr17, Syntenic

Variant origin

• Strain of Specimen: BALB/cByJ

Variant description

• Allele Type: QTL
• Inheritance: Dominant

Notes

Homozygosity for this allele in conjunction with homozygosity for ct is sufficient to explain the curly tail phenotype. J:29366 penetrance of ct mutation (versus 38% on STOCK): C57BL/6J (18.50%), BXD-8/Ty (17.73%), BALB/cByJ (7.90%), M. spretus (2.50%), CAST/Ei (0%) and MOLF/Ei (0%).

Mapping and Phenotype information for this QTL, its variants and associated markers

J:29366

(M. spretus x STOCK-ct/ct)F1 x STOCK-ct/ct and (BALB/cByJ x STOCK-ct/ct)F1 x STOCK-ct/ct interspecific backcross progeny were genotyped using 70 SSCP markers on 19 autosomes in a genome wide scan in an attempt to identify loci which modify the ct (curly tail) phenotype. Curly tail is coded for by a locus on mouse Chromosome 4. Various statistical parameters were used to identify a region of mouse Chromosome 17 that modified the ct phenotype. Authors have named this recessive locus mct1, modifier of curly-tail 1. By combining progeny from the two backcrosses an order of loci on mouse Chromosome 17 was indicated as: D17Mit113 - D17Mit134 - mct1 - D17Mit11 - D17Mit6 - D17Mit3 - D17Mit72 - D17Mit123.

References

• Original: J:29366 Letts VA, et al., A curly-tail modifier locus, mct1, on mouse chromosome 17. Genomics. 1995 Oct 10;29(3):719-24
• All: 1 reference(s)