Bik^tm1Ast
Targeted Allele Detail

Summary

• Symbol: Bik^tm1Ast
• Name: BCL2-interacting killer; targeted mutation 1, Andreas Strasser
• MGI ID: MGI:3612275
• Synonyms: bik^-
• Gene: Bik Location: Chr15:83411063-83428835 bp, + strand Genetic Position: Chr15, 39.4 cM
• Alliance: Bik^tm1Ast page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104487
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A beta-gal reporter gene was fused in frame with the endogenous ATG and a loxP-flanked neo cassette. The first and second coding exons of the locus, encoding the BH3 region, were removed. Crossing with mice expressing cre in the germline removed the floxed neo cassette. mRNA was absent in mutant liver, lung, heart, and kidney. (J:104487)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Bik Mutation: 11 strains or lines available

References

• Original: J:104487 Coultas L, et al., Proapoptotic BH3-only Bcl-2 family member Bik/Blk/Nbk is expressed in hemopoietic and endothelial cells but is redundant for their programmed death. Mol Cell Biol. 2004 Feb;24(4):1570-81
• All: 6 reference(s)