Six1^tm1Kwk
Targeted Allele Detail

Summary

• Symbol: Six1^tm1Kwk
• Name: sine oculis-related homeobox 1; targeted mutation 1, Kiyoshi Kawakami
• MGI ID: MGI:3612276
• Synonyms: Six1^-
• Gene: Six1 Location: Chr12:73088601-73093486 bp, - strand Genetic Position: Chr12, 30.34 cM
• Alliance: Six1^tm1Kwk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104488
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with an EGFP and a hygromycin-B-phosphotransferase gene. In situ hybridization failed to detect transcript in mutant embryos. (J:104488)

Expression

In Mice Carrying this Mutation:	184 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six1 Mutation: 19 strains or lines available

References

• Original: J:104488 Ozaki H, et al., Six1 controls patterning of the mouse otic vesicle. Development. 2004 Feb;131(3):551-62
• All: 16 reference(s)