Ntrk2^tm1Lfp
Targeted Allele Detail

Summary

• Symbol: Ntrk2^tm1Lfp
• Name: neurotrophic tyrosine kinase, receptor, type 2; targeted mutation 1, Luis F Parada
• MGI ID: MGI:3612277
• Synonyms: trkB^-
• Gene: Ntrk2 Location: Chr13:58954383-59281784 bp, + strand Genetic Position: Chr13, 31.2 cM
• Alliance: Ntrk2^tm1Lfp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104489
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The region encompassing the two transcription start sites and the first coding exon was deleted via homologous recombination. RT-PCR and in situ hybridization confirmed complete ablation of the locus. Neither truncated nor full-length transcript was detected. This allele was derived from Ntrk2^tm2Lfp. (J:104489)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ntrk2 Mutation: 66 strains or lines available

References

• Original: J:104489 Luikart BW, et al., In vivo role of truncated trkb receptors during sensory ganglion neurogenesis. Neuroscience. 2003;117(4):847-58
• All: 3 reference(s)