Smc1a^tm1Mbk
Targeted Allele Detail

Summary

• Symbol: Smc1a^tm1Mbk
• Name: structural maintenance of chromosomes 1A; targeted mutation 1, Michael B Kastan
• MGI ID: MGI:3612278
• Synonyms: Smc1^S957AS966A
• Gene: Smc1a Location: ChrX:150799386-150844969 bp, + strand Genetic Position: ChrX, 68.46 cM
• Alliance: Smc1a^tm1Mbk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104490
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted
• Mutation: Nucleotide substitutions
• Two serines were mutated to alanines at positions 957 and 966 in exon 19. (J:104490)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Smc1a Mutation: 10 strains or lines available

References

• Original: J:104490 Kitagawa R, et al., Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev. 2004 Jun 15;18(12):1423-38
• All: 3 reference(s)