Fscn2^tm2Sykk
Targeted Allele Detail

Summary

• Symbol: Fscn2^tm2Sykk
• Name: fascin actin-bundling protein 2; targeted mutation 2, Shinji Yokokura
• MGI ID: MGI:3612338
• Synonyms: Fscn2^g neo^-
• Gene: Fscn2 Location: Chr11:120252360-120258994 bp, + strand Genetic Position: Chr11, 84.08 cM
• Alliance: Fscn2^tm2Sykk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103713
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced by GFP. Cre mediated recombination removed a floxed neomycin selection cassette. Fluorescence was detected in the photoreceptors. (J:103713)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fscn2 Mutation: 39 strains or lines available

References

• Original: J:103713 Yokokura S, et al., Targeted disruption of FSCN2 gene induces retinopathy in mice. Invest Ophthalmol Vis Sci. 2005 Aug;46(8):2905-15
• All: 2 reference(s)