Slc4a3^tm1Cahb
Targeted Allele Detail

Summary

• Symbol: Slc4a3^tm1Cahb
• Name: solute carrier family 4 (anion exchanger), member 3; targeted mutation 1, Christian A Hubner
• MGI ID: MGI:3612402
• Gene: Slc4a3 Location: Chr1:75522688-75536075 bp, + strand Genetic Position: Chr1, 39.16 cM, cytoband C3
• Alliance: Slc4a3^tm1Cahb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104157
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 6-19 were removed via cre mediated recombination, thereby removing the sequence coding for transmembrane domains 1 to 7 of the predicted 12 transmembane domains of anion exchanger 3. Northern and Western blot failed to detect transcript and protein, respectively, in mutant brain and heart samples. (J:104157)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc4a3 Mutation: 42 strains or lines available

References

• Original: J:104157 Hentschke M, et al., Mice with a Targeted Disruption of the Cl-/HCO3- Exchanger AE3 Display a Reduced Seizure Threshold. Mol Cell Biol. 2006 Jan;26(1):182-91
• All: 2 reference(s)