Trpm5^tm1Sdmk
Targeted Allele Detail

Summary

• Symbol: Trpm5^tm1Sdmk
• Name: transient receptor potential cation channel, subfamily M, member 5; targeted mutation 1, Sami Damak
• MGI ID: MGI:3612408
• Synonyms: Trpm5^-, Trpm5 KO
• Gene: Trpm5 Location: Chr7:142625266-142648379 bp, - strand Genetic Position: Chr7, 88.11 cM
• Alliance: Trpm5^tm1Sdmk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104626
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Sequence encompassing 2.4 kb of the 5' flanking region comprising the promoter and exons 1-4, including the translation start site in exon 2, was deleted. Immunohistochemistry failed to detect protein in taste buds of mutant mice. (J:103852, J:122002)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trpm5 Mutation: 57 strains or lines available

References

• Original: J:104626 Rong M, et al., Signal Transduction of Umami Taste: Insights from Knockout Mice. Chem Senses. 2005 Jan;30(suppl_1):i33-i34
• All: 30 reference(s)