Lrat^tm1Log
Targeted Allele Detail

Summary

• Symbol: Lrat^tm1Log
• Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); targeted mutation 1, Lorraine J Gudas
• MGI ID: MGI:3612421
• Synonyms: Lrat^-
• Gene: Lrat Location: Chr3:82799889-82811281 bp, - strand Genetic Position: Chr3, 36.81 cM
• Alliance: Lrat^tm1Log page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104101
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 1, containing the ATG start codon, with a neomycin resistance gene flanked by loxP sites. Transcript was not detected in mutant kidney, intestine, brain, lung or liver samples by RT-PCR. (J:104101)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrat Mutation: 26 strains or lines available

References

• Original: J:104101 Liu L, et al., Disruption of the lecithin:retinol acyltransferase gene makes mice more susceptible to vitamin A deficiency. J Biol Chem. 2005 Dec 2;280(48):40226-34
• All: 4 reference(s)