Tg(Gnrh1-cre)1Rsp
Transgene Detail

Summary

• Symbol: Tg(Gnrh1-cre)1Rsp
• Name: transgene insertion 1, Rolf Sprengel
• MGI ID: MGI:3612443
• Synonyms: Tg^GnRH-iCre
• Transgene: Tg(Gnrh1-cre)1Rsp Location: unknown
• Alliance: Tg(Gnrh1-cre)1Rsp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gnrh1-cre)1Rsp expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gnrh1 (MGI:95789)

• Mutation details: The mouse gonadotropin-releasing hormone promoter was used to drive the expression of improved cre (icre). The icre was assembled from oligonucleotides to introduce silent base mutations corresponding to human codon-usage preferences, minimize CpG content, eliminate putative cryptic splice sites and alter the stop codon. Cre activity was detected in 97% of Gnrh immunopositive neurons and in a second population of cells, mainly the limbic system neurons. Four lines exhibiting high expression and three with low expression were obtained. This is a representative from those lines. (J:78663)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gnrh1 (mouse) Summary of all recombinase alleles driven by Gnrh1. Comparative matrix view of recombinase activities Alliance mouse Gnrh1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:78663 Shimshek DR, et al., Codon-improved Cre recombinase (iCre) expression in the mouse. Genesis. 2002 Jan;32(1):19-26
• All: 2 reference(s)