Tg(Gria2*586N)238.2Rsp
Transgene Detail

Summary

• Symbol: Tg(Gria2*586N)238.2Rsp
• Name: transgene insertion 238.2, Rolf Sprengel
• MGI ID: MGI:3612450
• Synonyms: GluR-B(N), GluR-B^Ntrans
• Transgene: Tg(Gria2*586N)238.2Rsp Location: unknown
• Alliance: Tg(Gria2*586N)238.2Rsp page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gria2*586N)238.2Rsp expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Gria2 (MGI:95809)

• Mutation details: This transgene contains multiple copies of a Gria2(N) minigene which encodes an asparagine (N) at the Q/R site. Specifically, the minigene is constructed from a 6 kb genomic DNA fragment comprising over 5 kb of the upstream region, including the Gria2 promoter, exon 1 and part of intron 1, a 1.1-kb KpnI fragment, itself the fusion of two PCR products connecting the murine intron 1 sequence to rat Gria2 cDNA, plus a fragment of Gria2 flip cDNA, mutated to contain an asparagine (N) codon for the Q/R site. Several lines were made with line L238.2 showing highest expression. (J:51845)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:51845 Feldmeyer D, et al., Neurological dysfunctions in mice expressing different levels of the Q/R site-unedited AMPAR subunit GluR-B. Nat Neurosci. 1999 Jan;2(1):57-64
• All: 2 reference(s)