Mdm4^tm2Glo
Targeted Allele Detail

Summary

• Symbol: Mdm4^tm2Glo
• Name: transformed mouse 3T3 cell double minute 4; targeted mutation 2, Guillermina Lozano
• MGI ID: MGI:3612473
• Synonyms: Mdm4^FM, Mdm4^FX
• Gene: Mdm4 Location: Chr1:132913843-132958325 bp, - strand Genetic Position: Chr1, 57.75 cM, cytoband G-G
• Alliance: Mdm4^tm2Glo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104114
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• A targeting vector was used to insert loxP sites to flank exon 2. (J:104114)

Disease models

Expression

In Mice Carrying this Mutation:	22 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mdm4 Mutation: 193 strains or lines available

References

• Original: J:104114 Grier JD, et al., Tissue-Specific Differences of p53 Inhibition by Mdm2 and Mdm4. Mol Cell Biol. 2006 Jan;26(1):192-8
• All: 15 reference(s)