Ahr^tm3.1Bra
Targeted Allele Detail

Summary

• Symbol: Ahr^tm3.1Bra
• Name: aryl-hydrocarbon receptor; targeted mutation 3.1, Christopher A Bradfield
• MGI ID: MGI:3612477
• Synonyms: Ahr^fx, Ahr^loxp
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^tm3.1Bra page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104388
• Parent Cell Line: GS1 (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was removed via cre-mediated recombination, leaving exon 2 floxed. Western blot of mutant livers confirmed protein was expressed as in wild-type animals. (J:104388)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ahr^tm3.1Bra

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 112 strains or lines available

References

• Original: J:104388 Walisser JA, et al., Aryl hydrocarbon receptor-dependent liver development and hepatotoxicity are mediated by different cell types. Proc Natl Acad Sci U S A. 2005 Dec 6;102(49):17858-63
• All: 92 reference(s)