Mylk2^tm1Jtst
Targeted Allele Detail

Summary

• Symbol: Mylk2^tm1Jtst
• Name: myosin, light polypeptide kinase 2, skeletal muscle; targeted mutation 1, James T Stull
• MGI ID: MGI:3612478
• Gene: Mylk2 Location: Chr2:152753272-152764988 bp, + strand Genetic Position: Chr2, 75.41 cM
• Alliance: Mylk2^tm1Jtst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104384
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace part of exon 6, intron 6 and exon 7, sequence encoding the ATP-binding sequence in the catalytic core. Western blot failed to detect protein in mutant mice. (J:104384)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mylk2 Mutation: 34 strains or lines available

References

• Original: J:104384 Zhi G, et al., Myosin light chain kinase and myosin phosphorylation effect frequency-dependent potentiation of skeletal muscle contraction. Proc Natl Acad Sci U S A. 2005 Nov 29;102(48):17519-24
• All: 1 reference(s)