Cmn3^CAST/Ei
QTL Variant Detail

Summary

• QTL variant: Cmn3^CAST/Ei
• Name: cardiac modifier of nmd 3; CAST/Ei
• MGI ID: MGI:3612510
• Synonyms: Cmn3^CAST/EiJ
• QTL: Cmn3 Location: unknown Genetic Position: Chr16, cM position of peak correlated region/allele: 34.22 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: CAST/Ei

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers resistance to dilated cardiomyopathy in males animals compared to C57BL/6J. (J:102748)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:102748

Loci modifying the dilated cardiomyopathy phenotype of nmd (neuromuscular degeneration) mutant mice were mapped in a population of (B6.CAST-Mnm^C Ighmbp2^nmd-2J x CAST/EiJ)F1 x B6.CAST-Mnm^C Ighmbp2^nmd-2J backcross animals. Genome scan was performedusing 134 polymorphic markers spaced 10 cM - 20 cM intervals apart. Prolonged lifespan was used to measure protection against dilated cardiomyopathy.

Cmn1 (cardiac modifier of nmd 1) mapped to 70 cM on mouse Chromosome 9 near D9Mit17 (LOD=5.56). The 95%confidence interval of Cmn1 spans 60 cM - 70 cM. This locus explains 8.2% of the variance. CAST/EiJ-derived alleles at Cmn1 confer resistance to development of dilated cardiomyopathy associated with the Ighmbp2^nmd-2J mutation.

Cmn2 mapped to 44 cM onmouse Chromosome 10 near D10Mit42 (LOD=7.95). The 95% confidence interval of Cmn2 spans 28 cM - 44 cM. This locus explains 12.1% of the variance. CAST/EiJ-derived alleles at Cmn2 confer resistance to development of dilated cardiomyopathy associated with the Ighmbp2^nmd-2J mutation.

Cmn3 mapped to 44 cM on mouse Chromosome 16 near D16Mit64 (LOD=4.28). The 95% confidence interval of Cmn3 spans 42 cM - 48 cM. This locus explains 6.2% of the variance. In male animals, CAST/EiJ-derived alleles at Cmn3 confer resistance to development of dilated cardiomyopathy associated with the Ighmbp2^nmd-2J mutation, whereas in females the C57BL/6J-derived allele confers resistance.

Two suggestive loci with C57BL/6J-derived alleles conferring resistance to dilated cardiomyopathy mapped to mouse Chromosomes 1 (LOD=3) and 5 (LOD=3.3).

References

• Original: J:102748 Maddatu TP, et al., Dilated cardiomyopathy in the nmd mouse: transgenic rescue and QTLs that improve cardiac function and survival. Hum Mol Genet. 2005 Nov 1;14(21):3179-89
• All: 1 reference(s)