Gdf3^tm1Mms
Targeted Allele Detail

Summary

• Symbol: Gdf3^tm1Mms
• Name: growth differentiation factor 3; targeted mutation 1, Michael M Shen
• MGI ID: MGI:3612535
• Synonyms: Bf-Gdf3
• Gene: Gdf3 Location: Chr6:122582362-122587046 bp, - strand Genetic Position: Chr6, 57.7 cM
• Alliance: Gdf3^tm1Mms page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104371
• Parent Cell Line: AB2.1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The prodomain was replaced with that of Xenopus Bmp2 with a FLAG or V5 epitope tag at the N-terminus of the mature ligand. The resulting fusion protein was expressed. Several proteins were detected by Western blot. (J:104371)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gdf3 Mutation: 40 strains or lines available

References

• Original: J:104371 Chen C, et al., The Vg1-related protein Gdf3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo. Development. 2006 Jan;133(2):319-29
• All: 1 reference(s)