Stk11^tm1.1Mlfr
Targeted Allele Detail

Summary

• Symbol: Stk11^tm1.1Mlfr
• Name: serine/threonine kinase 11; targeted mutation 1.1, Marsha L Frazier
• MGI ID: MGI:3612540
• Synonyms: Lkb1^-
• Gene: Stk11 Location: Chr10:79951637-79966516 bp, + strand Genetic Position: Chr10, 39.72 cM
• Alliance: Stk11^tm1.1Mlfr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104347
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Cre-mediated recombination resulted in the loss of exons 2-8. (J:104347)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk11 Mutation: 35 strains or lines available

References

• Original: J:104347 Wei C, et al., Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res. 2005 Dec 15;65(24):11297-303
• All: 5 reference(s)