Del(8Nat1-Nat2)1Kss
Targeted Allele Detail

Summary

• Symbol: Del(8Nat1-Nat2)1Kss
• Name: deletion, Chr 8, Kim S Sugamori 1
• MGI ID: MGI:3612793
• Synonyms: Nat1/2(-), Nat1/Nat2^tm1Kss, Nat1^tm1Kss
• Gene: Del(8Nat1-Nat2)1Kss Location: unknown Genetic Position: Chr8, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:103885
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intergenic deletion, Intragenic deletion
• Del(8Nat1-Nat2)1Kss involves 2 genes/genome features (Nat1, Nat2) View all
• Mutation details: A neomycin resistance gene was inserted to delete ~11 kb of sequence, including the entire coding region of Nat1 and most of the coding region of Nat2. RT-PCR failed to detect transcript of either gene in mutants. (J:103885)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(8Nat1-Nat2)1Kss Mutation: 0 strains or lines available

References

• Original: J:103885 Sugamori KS, et al., Generation and functional characterization of arylamine N-acetyltransferase Nat1/Nat2 double-knockout mice. Mol Pharmacol. 2003 Jul;64(1):170-9
• All: 6 reference(s)