Nkrf^tm1.1Hjh
Targeted Allele Detail

Summary

• Symbol: Nkrf^tm1.1Hjh
• Name: NF-kappaB repressing factor; targeted mutation 1.1, Hansjorg Hauser
• MGI ID: MGI:3612957
• Synonyms: NRF-KO
• Gene: Nkrf Location: ChrX:36151193-36167166 bp, - strand Genetic Position: ChrX, 21.3 cM, cytoband A2
• Alliance: Nkrf^tm1.1Hjh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104192
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 2 and part of intron 1 including the splice acceptor were deleted via cre mediated recombination. The predicted mRNA would contain just the 5' part of the intron sequence as multiple stop codons in the intron prevent translation of the unspliced mRNA. This potential translation product would have 45 amino acids. Northern blot did not detect transcript in mutants. (J:104192)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkrf Mutation: 9 strains or lines available

References

• Original: J:104192 Froese N, et al., Innate Immune Responses in NF-{kappa}B-Repressing Factor-Deficient Mice. Mol Cell Biol. 2006 Jan;26(1):293-302
• All: 1 reference(s)