P2rx4^tm1Ando
Targeted Allele Detail

Summary

• Symbol: P2rx4^tm1Ando
• Name: purinergic receptor P2X, ligand-gated ion channel 4; targeted mutation 1, Joji Ando
• MGI ID: MGI:3612982
• Synonyms: P2rx4^-
• Gene: P2rx4 Location: Chr5:122845607-122867801 bp, + strand Genetic Position: Chr5, 62.53 cM
• Alliance: P2rx4^tm1Ando page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104459
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3-5 were replaced by a neomycin resistance cassette flanked by two loxP sites and the neo cassette was subsequently removed with cre recombinase. Northern blot failed to detect transcript in mutant pulmonary microvessel endothelial cells. Protein was not detected by immunological assay. (J:104459)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any P2rx4 Mutation: 26 strains or lines available

References

• Original: J:104459 Yamamoto K, et al., Impaired flow-dependent control of vascular tone and remodeling in P2X4-deficient mice. Nat Med. 2006 Jan;12(1):133-7
• All: 7 reference(s)