TgTn(sb-T2/Onc)76Dla
Transgene Detail

Summary

• Symbol: TgTn(sb-T2/Onc)76Dla
• Name: transgenic transposon concatemer 76, David A Largaespada
• MGI ID: MGI:3612986
• Synonyms: SB LC76
• Transgene: TgTn(sb-T2/Onc)76Dla Location: unknown Genetic Position: Chr1, Syntenic
• Alliance: TgTn(sb-T2/Onc)76Dla page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Transposon concatemer)
• Mutation: Insertion
• Mutation details: A concatemer of sleeping beauty transposable elements each consisting of the inverted repeat direct repeat sequence specific for sleeping beauty transposase flanking splice acceptor sites and poly A signals in both orientations. Between the splice acceptor sites is 5' long terminal repeat sequence from the murine stem cell virus followed by a splice donor site. This construct can create both loss-of-function and gain-of-function mutations. In line 76 the concatemer is integrated into chromosome 1. Around 25 copies of the construct are integrated in this line and the construct is unmethylated. (J:99991)

Disease models

Tumor Data

List all tumor models in MMHCdb carrying TgTn(sb-T2/Onc)76Dla

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:99991 Collier LS, et al., Cancer gene discovery in solid tumours using transposon-based somatic mutagenesis in the mouse. Nature. 2005 Jul 14;436(7048):272-6
• All: 15 reference(s)