Adora3^{tm1(ADORA3)Msth}
Targeted Allele Detail

Summary

• Symbol: Adora3^{tm1(ADORA3)Msth}
• Name: adenosine A3 receptor; targeted mutation 1, Mitsuo Satoh
• MGI ID: MGI:3613017
• Synonyms: A3AR^h
• Gene: Adora3 Location: Chr3:105811737-105816244 bp, + strand Genetic Position: Chr3, 46.45 cM, cytoband F3
• Alliance: Adora3^{tm1(ADORA3)Msth} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104494
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Adora3^{tm1(ADORA3)Msth} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ADORA3 (140)

  Adora3

  (MGI:104847)

• Mutation details: The cDNA for human ADORA3, encompassing sequence from the ATG to the TAG stop codon, was inserted into exon 1 at the ATG. RT-PCR analysis detected human transcript at the same levels and with the same distribution as endogenous transcript in wild-type mice. No expression of the mouse transcript was detected in mutant mice. (J:104494, J:104495)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adora3 Mutation: 24 strains or lines available

References

• Original: J:104494 Yamano K, et al., Human adenosine A(3) receptor leads to intracellular Ca(2+) mobilization but is insufficient to activate the signaling pathway via phosphoinositide 3-kinase gamma in mice. Biochem Pharmacol. 2005 Nov 15;70(10):1487-96
• All: 2 reference(s)