Aqp8^tm1Ask
Targeted Allele Detail

Summary

• Symbol: Aqp8^tm1Ask
• Name: aquaporin 8; targeted mutation 1, Alan S Verkman
• MGI ID: MGI:3613030
• Synonyms: Aqp8^-, AQP8^-
• Gene: Aqp8 Location: Chr7:123061517-123067226 bp, + strand Genetic Position: Chr7, 67.42 cM, cytoband F3
• Alliance: Aqp8^tm1Ask page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104681
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4-6 were replaced with a neomycin cassette. Northern blot failed to detect transcript and Western blot confirmed the absence of protein in mutant submandibular gland, liver, colon and testes. (J:104681)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aqp8 Mutation: 15 strains or lines available

References

• Original: J:104681 Yang B, et al., Phenotype analysis of aquaporin-8 null mice. Am J Physiol Cell Physiol. 2005 May;288(5):C1161-70
• All: 7 reference(s)