Dio1^tm1Vag
Targeted Allele Detail

Summary

• Symbol: Dio1^tm1Vag
• Name: deiodinase, iodothyronine, type I; targeted mutation 1, Valerie Anne Galton
• MGI ID: MGI:3613031
• Synonyms: D1KO
• Gene: Dio1 Location: Chr4:107148662-107164365 bp, - strand Genetic Position: Chr4, 50.18 cM
• Alliance: Dio1^tm1Vag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104508
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon two, containing the TGA selenocysteine codon, was replaced with the neo cassette. Protein activity was not detected in mutant liver, kidney, thyroid or pituitary tissues. (J:104508)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Dio1 Mutation: 16 strains or lines available

Notes

ES cell line = DS2A

References

• Original: J:104508 Schneider MJ, et al., Targeted disruption of the type 1 selenodeiodinase gene (Dio1) results in marked changes in thyroid hormone economy in mice. Endocrinology. 2006 Jan;147(1):580-9
• All: 13 reference(s)