Nr3c2^tm2.1Gsc
Targeted Allele Detail

Summary

• Symbol: Nr3c2^tm2.1Gsc
• Name: nuclear receptor subfamily 3, group C, member 2; targeted mutation 2.1, Gunther Schutz
• MGI ID: MGI:3613035
• Synonyms: MR^null
• Gene: Nr3c2 Location: Chr8:77626422-77971641 bp, + strand Genetic Position: Chr8, 36.34 cM
• Alliance: Nr3c2^tm2.1Gsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104549
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Cre mediated excision was used to remove exon 3, which which encode the first zinc finger of the mineralocorticoid receptor DNA binding domain. (J:104549)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nr3c2 Mutation: 53 strains or lines available

References

• Original: J:104549 Berger S, et al., Loss of the limbic mineralocorticoid receptor impairs behavioral plasticity. Proc Natl Acad Sci U S A. 2006 Jan 3;103(1):195-200
• All: 1 reference(s)