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Txniptm1Jjy
Targeted Allele Detail
Summary
Symbol: Txniptm1Jjy
Name: thioredoxin interacting protein; targeted mutation 1, Junji Yodoi
MGI ID: MGI:3613036
Synonyms: TBP-2-
Gene: Txnip  Location: Chr3:96465273-96469173 bp, + strand  Genetic Position: Chr3, 41.93 cM, cytoband F2.2
Alliance: Txniptm1Jjy page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:104563
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced exons 1-4. Absence of transcript in mutant heart, thymus, spleen, liver and muscle was confirmed by Northern blot. (J:104563)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Txnip Mutation:  49 strains or lines available
References
Original:  J:104563 Oka S, et al., Impaired fatty acid utilization in thioredoxin binding protein-2 (TBP-2)-deficient mice: a unique animal model of Reye syndrome. FASEB J. 2006 Jan;20(1):121-3
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory