Nr3c2^tm1Krst
Targeted Allele Detail

Summary

• Symbol: Nr3c2^tm1Krst
• Name: nuclear receptor subfamily 3, group C, member 2; targeted mutation 1, Henk Karst
• MGI ID: MGI:3613053
• Synonyms: MR^loxP
• Gene: Nr3c2 Location: Chr8:77626422-77971641 bp, + strand Genetic Position: Chr8, 36.34 cM
• Alliance: Nr3c2^tm1Krst page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104691
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites flanked exon 3, which encodes the first zinc finger of the mineralocorticoid receptor DNA binding domain. (J:104691)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Nr3c2^tm1Krst/Nr3c2^tm1Krst Tg(Camk2a-cre)2Gsc/?	involves: FVB/N

Phenotypes:

Affected Systems	cn1
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nervous system	√
abnormal miniature excitatory postsynaptic currents	√

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nr3c2 Mutation: 53 strains or lines available

References

• Original: J:104691 Karst H, et al., Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19204-7
• All: 1 reference(s)