P2ry2^tm1Bhk
Targeted Allele Detail

Summary

• Symbol: P2ry2^tm1Bhk
• Name: purinergic receptor P2Y, G-protein coupled 2; targeted mutation 1, Beverly Koller
• MGI ID: MGI:3613160
• Synonyms: P2ry2^tm1Bouc, P2Y2^-, P2Y2-R^-
• Gene: P2ry2 Location: Chr7:100645775-100661260 bp, - strand Genetic Position: Chr7, 54.47 cM, cytoband F1
• Alliance: P2ry2^tm1Bhk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57617
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin selection cassette replaced a genomic fragment corresponding to base pairs 552 - 1149 of the published cDNA. Northern blot analysis on RNA derived from kidney of homozygous mice confirmed that no detectable transcript is expressed from this allele. (J:57617)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any P2ry2 Mutation: 18 strains or lines available

References

• Original: J:57617 Homolya L, et al., Nucleotide-regulated calcium signaling in lung fibroblasts and epithelial cells from normal and P2Y(2) receptor (-/-) mice. J Biol Chem. 1999 Sep 10;274(37):26454-60
• All: 68 reference(s)