Pj1^BALB/cHeA
QTL Variant Detail

Summary

• QTL variant: Pj1^BALB/cHeA
• Name: paralysis, JHMV-induced 1; BALB/cHeA
• MGI ID: MGI:3613181
• QTL: Pj1 Location: unknown Genetic Position: Chr7, Syntenic

Variant origin

• Strain of Specimen: BALB/cHeA

Variant description

• Allele Type: QTL

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:1357

Resistance to mouse coronavirus strain JHM (JHMV) mapped to mouse Chromosome 7 near Itgal (60 cM, formerly Ly-15) in 13 recombinant inbred (RI) strains derived from BALB/cHeA and STS/A progenitor strains. This locus is named Pj1 (paralysis, JHMV-induced 1). Parental strain BALB/cHeA is susceptible to JHMV (100% mortality 2 weeks after innoculation) whereas parental strain STS/A exhibits partial resistance (30% mortality 2 weeks after innoculation). The strain distibution pattern of 92 genes showed a correlation between Pj1 and Itgal. Since the mortality of RI animals varied between 72% and 100% and the onset of paralysis varied considerably it is thought that resistance to JHMV is under multifactorial control.

References

• Original: J:1357 Kyuwa S, et al., Acute and late disease induced by murine coronavirus, strain JHM, in a series of recombinant inbred strains between BALB/cHeA and STS/A mice. Microb Pathog. 1992 Feb;12(2):95-104
• All: 1 reference(s)