Abca1^tm2Jp
Targeted Allele Detail

Summary

• Symbol: Abca1^tm2Jp
• Name: ATP-binding cassette, sub-family A member 1; targeted mutation 2, John S Parks
• MGI ID: MGI:3613250
• Synonyms: Abca1^-
• Gene: Abca1 Location: Chr4:53030787-53159895 bp, - strand Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
• Alliance: Abca1^tm2Jp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104719
• Parent Cell Line: ESVJ (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 17-22 of the locus, which encode the first nucleotide binding domain. (J:104719)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Abca1 Mutation: 90 strains or lines available

References

• Original: J:104719 Lee JY, et al., HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney. J Lipid Res. 2005 Oct;46(10):2233-45
• All: 7 reference(s)