Smtn^tm2Gve
Targeted Allele Detail

Summary

• Symbol: Smtn^tm2Gve
• Name: smoothelin; targeted mutation 2, Guillaume van Eys
• MGI ID: MGI:3613293
• Synonyms: Smnt-B^-
• Gene: Smtn Location: Chr11:3467522-3489337 bp, - strand Genetic Position: Chr11, 2.47 cM, cytoband A2-A3
• Alliance: Smtn^tm2Gve page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104648
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3 through 7 were replaced with a neomycin gene. Q-PCR showed absence of the B transcript in the aorta, femoral artery, and jejunum. No affect upon the A transcript was detected. (J:158046)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smtn Mutation: 45 strains or lines available

Notes

ES Cell Line: L129/Sv

References

• Original: J:104648 Niessen P, et al., Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice. Gastroenterology. 2005 Nov;129(5):1592-601
• All: 2 reference(s)