Spink1^tm1Kymm
Targeted Allele Detail

Summary

• Symbol: Spink1^tm1Kymm
• Name: serine peptidase inhibitor, Kazal type 1; targeted mutation 1, Ken-ichi Yamamura
• MGI ID: MGI:3613294
• Synonyms: Spink3^-
• Gene: Spink1 Location: Chr18:43861134-43870302 bp, - strand Genetic Position: Chr18, 23.47 cM, cytoband B3
• Alliance: Spink1^tm1Kymm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104647
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neo flanked by the mutated loxP sites lox71 and lox2272 was inserted immediately upstream of the ATG in exon 1. Northern blot failed to detect transcript and Western blot failed to detect protein in mutants. (J:104647)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Spink1 Mutation: 14 strains or lines available

References

• Original: J:104647 Ohmuraya M, et al., Autophagic cell death of pancreatic acinar cells in serine protease inhibitor Kazal type 3-deficient mice. Gastroenterology. 2005 Aug;129(2):696-705
• All: 2 reference(s)