Ccr5^tm1Blck
Targeted Allele Detail

Summary

• Symbol: Ccr5^tm1Blck
• Name: C-C motif chemokine receptor 5; targeted mutation 1, Bruno Luckow
• MGI ID: MGI:3613371
• Synonyms: Ccr5^-
• Gene: Ccr5 Location: Chr9:123921557-123934153 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr5^tm1Blck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105072
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A lacZ-neo cassette replaced much of the single exon. Absence of transcript was confirmed by RNase-protection assay. (J:105072)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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hm1	Ccr5^tm1Blck/Ccr5^tm1Blck	B6.129P2-Ccr5^tm1Blck
cx2	Apoe^tm1Unc/Apoe^tm1Unc Ccr5^tm1Blck/Ccr5^tm1Blck	involves: 129P2/OlaHsd * C57BL/6

Phenotypes:

Affected Systems	hm1	cx2
show or hide all annotated terms
cardiovascular system	√	√
atherosclerotic lesions		√
abnormal response to cardiac infarction	√
cellular	√
abnormal cellular extravasation	√
abnormal leukocyte adhesion	√
hematopoietic system	√	√
abnormal cellular extravasation	√
abnormal leukocyte adhesion	√
decreased T cell number		√
abnormal mononuclear phagocyte morphology		√
abnormal lymphocyte physiology		√
homeostasis/metabolism	√
abnormal response to cardiac infarction	√
immune system	√	√
abnormal cellular extravasation	√
abnormal leukocyte adhesion	√
decreased T cell number		√
abnormal mononuclear phagocyte morphology		√
abnormal lymphocyte physiology		√
abnormal cytokine secretion		√
decreased interferon-gamma secretion		√
increased interleukin-10 secretion		√
increased length of allograft survival	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 7 strains available Cell Lines: 0 lines available
• Carrying any Ccr5 Mutation: 31 strains or lines available

References

• Original: J:105072 Luckow B, et al., Reduced intragraft mRNA expression of matrix metalloproteinases Mmp3, Mmp12, Mmp13 and Adam8, and diminished transplant arteriosclerosis in Ccr5-deficient mice. Eur J Immunol. 2004 Sep;34(9):2568-78
• All: 9 reference(s)