Cntn6^tm1Kwat
Targeted Allele Detail

Summary

• Symbol: Cntn6^tm1Kwat
• Name: contactin 6; targeted mutation 1, Kazutada Watanabe
• MGI ID: MGI:3613462
• Synonyms: NB-3^-
• Gene: Cntn6 Location: Chr6:104469751-104840367 bp, + strand Genetic Position: Chr6, 48.93 cM, cytoband E2
• Alliance: Cntn6^tm1Kwat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104862
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The genomic region encoding the secretion signal and part of the first Ig-domain were replaced with a lacZ and neo cassette. LacZ expression was detected in the accessory olfactory bulb, anterodorsal thalamic nuclei, inferior colliculi, layer 5 of the cerebral cortex and the cerebellum. Western blot failed to detect protein in mutant brains. (J:61081, J:104862)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cntn6 Mutation: 64 strains or lines available

References

• Original: J:104862 Takeda Y, et al., Impaired motor coordination in mice lacking neural recognition molecule NB-3 of the contactin/F3 subgroup. J Neurobiol. 2003 Sep 5;56(3):252-65
• All: 10 reference(s)