Mapk8ip1^tm1Plhn
Targeted Allele Detail

Summary

• Symbol: Mapk8ip1^tm1Plhn
• Name: mitogen-activated protein kinase 8 interacting protein 1; targeted mutation 1, Pyung-Lim Han
• MGI ID: MGI:3613487
• Synonyms: jip1^-
• Gene: Mapk8ip1 Location: Chr2:92214021-92231608 bp, - strand Genetic Position: Chr2, 50.99 cM, cytoband E1
• Alliance: Mapk8ip1^tm1Plhn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104842
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced sequence encoding most of the N-terminal region of the protein, including the JNK-binding domain. Absence of transcript and protein was confirmed in mutant brain by Northern and Western blot, respectively. (J:104842)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mapk8ip1 Mutation: 34 strains or lines available

References

• Original: J:104842 Im JY, et al., Repression of phospho-JNK and infarct volume in ischemic brain of JIP1-deficient mice. J Neurosci Res. 2003 Oct 15;74(2):326-32
• All: 3 reference(s)