Chrm5^tm1Minm
Targeted Allele Detail

Summary

• Symbol: Chrm5^tm1Minm
• Name: cholinergic receptor, muscarinic 5; targeted mutation 1, Minoru Matsui
• MGI ID: MGI:3613514
• Synonyms: Chrm5^-, M5 KO
• Gene: Chrm5 Location: Chr2:112309516-112311114 bp, - strand Genetic Position: Chr2, 57.02 cM
• Alliance: Chrm5^tm1Minm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:105126
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a PGK-neo replaced most of the coding sequence. RT-PCR failed to detect transcript in mutant brains. (J:105126)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Chrm5 Mutation: 40 strains or lines available

References

• Original: J:105126 Nakamura T, et al., M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice. J Physiol. 2004 Jul 15;558(Pt 2):561-75
• All: 9 reference(s)