Aco1^tm1.2Mwh
Targeted Allele Detail

Summary

• Symbol: Aco1^tm1.2Mwh
• Name: aconitase 1; targeted mutation 1.2, Matthias W Hentze
• MGI ID: MGI:3613519
• Synonyms: Irp1^delta
• Gene: Aco1 Location: Chr4:40143081-40198338 bp, + strand Genetic Position: Chr4, 20.24 cM
• Alliance: Aco1^tm1.2Mwh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:104538
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The floxed exon 3 was removed from Aco1^tm1.1Mwh by mating with mice expressing Tg(Pgk1-cre)1Lni, creating a null allele. Removal of exon 3 creates a frameshift with premature termination of translation in exon 4. Western blotting confirmed absence of protein in kidney, duodenum, liver and spleen extracts. (J:103414, J:104538)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Aco1 Mutation: 51 strains or lines available

References

• Original: J:104538 Galy B, et al., Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. RNA. 2004 Jul;10(7):1019-25
• All: 7 reference(s)