Arhgdia^tm1Ytk
Targeted Allele Detail

Summary

• Symbol: Arhgdia^tm1Ytk
• Name: Rho GDP dissociation inhibitor alpha; targeted mutation 1, Yoshimi Takai
• MGI ID: MGI:3613573
• Synonyms: Rho GDIalpha -
• Gene: Arhgdia Location: Chr11:120468930-120472450 bp, - strand Genetic Position: Chr11, 84.29 cM
• Alliance: Arhgdia^tm1Ytk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57995
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 3kb MC1-neomycin resistance cassette replaced all three exons. Western blot analysis did not detect protein in spleen lysates from homozygous mutant mice. (J:57995)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Arhgdia Mutation: 18 strains or lines available

References

• Original: J:57995 Togawa A, et al., Progressive impairment of kidneys and reproductive organs in mice lacking Rho GDIalpha. Oncogene. 1999 Sep 23;18(39):5373-80
• All: 5 reference(s)