Srpk3^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Srpk3^tm1Eno
• Name: serine/arginine-rich protein specific kinase 3; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3613582
• Synonyms: Srpk3-null
• Gene: Srpk3 Location: ChrX:72818011-72822531 bp, + strand Genetic Position: ChrX, 37.41 cM
• Alliance: Srpk3^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100494
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129/Sv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Parts of exons 1 and 5, and the intervening region were replaced with a lacZ/neomycin resistance cassette. Northern blot analysis indicated that the normal transcript was undetectable in heart and skeletal muscle of homozygous mice. (J:100494)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Srpk3 Mutation: 10 strains or lines available

References

• Original: J:100494 Nakagawa O, et al., Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2. Genes Dev. 2005 Sep 1;19(17):2066-77
• All: 1 reference(s)