Chlq4^C3H/HeJ
QTL Variant Detail

Summary

• QTL variant: Chlq4^C3H/HeJ
• Name: circulating hormone level QTL 4; C3H/HeJ
• MGI ID: MGI:3613675
• QTL: Chlq4 Location: unknown Genetic Position: Chr4, cM position of peak correlated region/allele: 46.99 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: C3H/HeJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased serum thyroxine levels at 4 and 15 months of age compared to DBA/2J. (J:104331)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Notes

This allele exhibits paternal inheritance.

Mapping and Phenotype information for this QTL, its variants and associated markers

J:104331

Linkage analysis was performed on 1,108 animals from a (BALB/cJ x C57BL/6J)F1 x (C3H/JeJ x DBA/2J)F1 cross to identify QTL associated with expression of four different hormones: insulin-like growth factor 1 (IGF-1), corticosteroid, leptin, and thyroxine (T4). Serum IGF-1, leptin, and T4 were assessed at 4 and 15 months of age, and fecal corticosteroid was assessed at 17 months of age. 87 polymorphic markers and 164 bi-allelic markers were used for the genome scan (average marker distance = 15 cM to 20 cM).

Chlq1 (circulating hormone level QTL 1) mapped o 95.8 cM (174.31 Mb) on mouse Chromosome 1 near D1Mit206. This locus exhibits maternal inheritance, is linked to IGF-1 levels at 4 months of age, and shows suggestive linkage to serum IGF-1 levels at 15 months of age. BALB/cJ-derived alleles at Chlq1 confer increased serum IGF-1 levels compared to C57BL/6J. Chlq1 is also linked to fecal corticosteroid levels at 17 months of age. The effect is paternally inherited and peaks at 80 cM (161.3 Mb). DBA/2J-derived alleles at Chlq1 confer increased fecal corticosteroids compared to C3H/HeJ-derived alleles.

Chlq2 mapped to 38.3 cM (80.35 Mb) on mouse Chromosome 3 near D3Mit25. This locus exhibits maternal inheritance and is linked to serum IGF-1 levels at 15 months of age. C57BL/6J-derived alleles at Chlq2 confer increased serum IGF-1 compared to BALB/cJ-derived alleles. Chlq3 mapped to 70.3 cM (143.7 Mb) near D3Mit127. This locus exhibits paternal inheritance and is linked to serum leptin levels at 4 months of age (suggestive linkage to serum leptin at 15 months of age). C3H/HeJ-derived alleles at Chlq3 confer increased serum leptin compared to DBA/2J-derived alleles.

Serum T4 levels at 4 and 15 months of age mapped to 49.6 cM (100.28 Mb) on mouse Chromosome 4 near D4Mit155. This locus exhibits paternal inheritance and is named Chlq4 (circulating hormone level QTL 4). C3H/HeJ-derived alleles at Chlq4 confer increased serum T4 compared to DBA/2J-derived alleles.

Chlq5 mapped to 41 cM (88.1 Mb) on mouse Chromosome 8 near D8Mit51. This locus exhibits maternal inheritance and is linked to serum IGF-1 levels at 15 months of age. Chlq5 also shows suggestive linkage to serum IGF-1 and serum T4 at 4 months of age. C57BL/6J-derived alleles at Chlq5 confer increased serum IGF-1 compared to BALB/cJ-derived alleles.

Chlq6 mapped to 49 cM (90.39 Mb) on mouse Chromosome 10 near D10Mit230. This locus exhibits paternal inheritance and is linked to serum IGF-1 levels at 4 months of age. C3H/HeJ-derived alleles at Chlq6 confer increased IGF-1 compared to DBA/2J.

Linkage to serum T4 levels at 15 months of age mapped to 21 cM (51.35 Mb) on mouse Chromosome 15 near D15Mit100. This locus exhibits maternal inheritance and is named Chlq7. BALB/cJ-derived alleles at Chlq7 confer increased serum T4 compared to C57BL/6J-derived alleles. Chlq7 also shows suggestive linkage to serum IGF-1 levels at 15 months of age and serum T4 levels at 4 months of age.

Chlq8 mapped to 10 cM (24.56 Mb) on mouse Chromosome 17 near D17Mit46 in linkage to serum T4 levels at 4 months of age. Chlq8 exhibits paternal inheritance with C3H/HeJ-derived alleles conferring increased serum T4 compared to DBA/2J-derived alleles.

References

• Original: J:104331 Harper JM, et al., Quantitative trait loci for insulin-like growth factor I, leptin, thyroxine, and corticosterone in genetically heterogeneous mice. Physiol Genomics. 2003 Sep 29;15(1):44-51
• All: 1 reference(s)