Bax^tm1Ofxa
Targeted Allele Detail

Summary

• Symbol: Bax^tm1Ofxa
• Name: BCL2-associated X protein; targeted mutation 1, Osborne FX Almeida
• MGI ID: MGI:3613737
• Synonyms: bax -
• Gene: Bax Location: Chr7:45111121-45116322 bp, - strand Genetic Position: Chr7, 29.32 cM, cytoband B5
• Alliance: Bax^tm1Ofxa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61471
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector containing a lacZ gene and an RSV-neomycin resistance cassette replaced most of the protein coding sequence in the first four exons. Western blot analysis did not detect protein in hippocampi from homozygous mutant mice. (J:61471)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bax Mutation: 24 strains or lines available

References

• Original: J:61471 Almeida OF, et al., Subtle shifts in the ratio between pro- and antiapoptotic molecules after activation of corticosteroid receptors decide neuronal fate. FASEB J. 2000 Apr;14(5):779-90
• All: 1 reference(s)