F10^tm1Edr
Targeted Allele Detail

Summary

• Symbol: F10^tm1Edr
• Name: coagulation factor X; targeted mutation 1, Elliot D Rosen
• MGI ID: MGI:3613747
• Synonyms: FX^-
• Gene: F10 Location: Chr8:13087308-13106676 bp, + strand Genetic Position: Chr8, 5.73 cM
• Alliance: F10^tm1Edr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61230
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced 18kb of sequence including exons 2-8, which encode the mature protein. RT-PCR analysis did not detect transcript in liver from homozygous E17.5 mutant embryos. Immunohistochemical analysis did not detect protein in liver sections from homozygous E17.5 mutant embryos. (J:61230)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any F10 Mutation: 29 strains or lines available

References

• Original: J:61230 Dewerchin M, et al., Blood coagulation factor X deficiency causes partial embryonic lethality and fatal neonatal bleeding in mice. Thromb Haemost. 2000 Feb;83(2):185-90
• All: 1 reference(s)