Rmp1^C57BL/6J
QTL Variant Detail

Summary

• QTL variant: Rmp1^C57BL/6J
• Name: resistance to mousepox; C57BL/6J
• MGI ID: MGI:3613792
• QTL: Rmp1 Location: unknown Genetic Position: Chr6, Syntenic

Variant origin

• Strain of Specimen: C57BL/6J

Variant description

• Allele Type: QTL
• Inheritance: Dominant

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:28150

Rmp1 (resistance to mousepox 1) is a locus on distal mouse Chromosome 6 near Prh1 (63.6 cM; formerly Prp) conferring susceptibility to ectromelia virus. Rmp1 was provisionally mapped in a series of 25 recombinant inbred strains derived from C57BL/6J and DBA/2J. Inbred strain DBA/2J is highly susceptible to infection with ectromelia virus whereas inbred strain C57BL/6J is resistant. 101 male animals from a (C57BL/6J x DBA/2J)F1 x DBA/2J backcross were challenged with 10⁵ PFU of Moscow strain ectromelia virus, and of these animals 18 died and 83 survived. All 18 animals that died were homozygous for DBA/2J-derived alleles at Prh1. The experiment was repeated in a population of 42 castrated male (C57BL/6J x DBA/2J)F1 x DBA/2J animals with similar results.All susceptible animals were homozygous for DBA/2J-derived alleles on chromosome 6 from 51 cM - 63 cM, a region that includes the Klrb1c (62.1 cM) locus. Both experiments support the hypothesis that a locus associated with ecromelia virus susceptibility named Rmp1 is located near Prh1 at 63.6 cM. A previously identified cytomegalovirus susceptibility locus named Klra8 (62.69 cM; formerly Cmv1) maps near Rmp1.

References

• Original: J:28150 Delano ML, et al., Innate resistance to lethal mousepox is genetically linked to the NK gene complex on chromosome 6 and correlates with early restriction of virus replication by cells with an NK phenotype. J Virol. 1995 Sep;69(9):5875-7
• All: 1 reference(s)